HIV disease progression exerts a selective impact on putative anti-HIV microbicides in cervicovaginal lavage fluid.

<p>(A) CVL levels of human beta defensin 2 (HBD2) were significantly lower among women with CD4<200 cells/µl. (B) CVL levels of Elafin were significantly higher among women with CD4<200 cells/µl. (C) There was a trend toward lower CVL levels of macrophage inflammatory protein-3 alpha (MIP-3α) among women with CD4<200 cells/µl. (D) CVL levels of secretory leukocyte protease inhibitor were higher among women with CD4<200 cells/µl. Bars depict median, interquartile range and 95% confidence intervals; P values derived via Kruskal-Wallis tests.