Vaccine Comparisons of Three SARS-CoV Vaccines, Experiment 1.

<p>Serum neutralizing (neut) antibody and lung virus titers for each vaccine dosage group. A. Geometric mean serum antibody titer as log₂ and standard error of the mean (S.E.) on day 56 for each vaccine dosage group. Seven to eight mice per group. Vaccines: double inactivated whole virus (DIV), recombinant S protein (SV), viral-like particle vaccine (VLP), with alum (+A). Five mice per group were given 0.1 ml of vaccine intramuscularly on days 0 and 28. B. Geometric mean virus titer (log₁₀ TCID₅₀/g) and standard error of the mean (S.E.) in lungs on day 58 (two days after SARS-CoV challenge) for each vaccine dosage group. Analyses: A. GMT with compared to without alum: DIV p>.05, VLP p>.05, SV p = .001. GMT for different vaccine dosage: DIV with alum p = .007, DIV without alum p>.05, SV with alum p = .028, SV without alum p = .01. Multiple regression: GMT increased for alum p = .012 and dosage p<.001, for SV alum only p = .001. B. GMT for all DIV groups not different p>.05, GMT for SV group without alum p .008 and with alum p .023. GMT for VLP group is not different p>.05.