Inhibition of UCH-L1 activity does not affect hippocampal mRNA expression levels of a-syn.
- Anna E. Cartier (326412)
- Kiren Ubhi (222926)
- Brian Spencer (222903)
- Ruben A. Vazquez-Roque (326415)
- Kori Ann Kosberg (326416)
- Lawrence Fourgeaud (326418)
- Priya Kanayson (326419)
- Christina Patrick (222916)
- Edward Rockenstein (222885)
- Gentry N. Patrick (239592)
- Eliezer Masliah (2942)
Publication date
February 2013
DOIAbstract
<p>Total RNA was extracted from hippocampal tissues of non tg and a-syn tg mice treated with or without LDN, and analyzed by real-time PCR for expression of murine a-syn (ma-syn) (A) and human a-syn (ha-syn) (B). a-syn mRNA expression levels for all groups were normalized to those in control non tg mice. N = 6 mice per group. * Indicates a significant difference between ha-syn mRNA levels in untreated non tg and a-syn tg mice, P<0.0001. Mean values ± SEM are shown.</p
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