Ribbon representation of the human PGK1.

<p>Three-dimensional structure of open (A) and closed (B) human PGK1. The figures were generated from the atomic coordinates of Protein Data Bank, entry 2XE7 and 2WZC, using the Swiss-Pdb viewer (<a href="http://expasy.org/spdbv/" target="_blank">http://expasy.org/spdbv/</a>). The black spheres indicate the Cα atoms of the amino acid residues subjected to mutagenesis. The arrows point to the substrates binding sites.