Ultrastructural characterization of the SVZ from ENU-treated animals.

<p>The SVZ of treated animals was altered after ENU-exposure. (A) The type A cells located in the dorsal horn of the SVZ in ENU animals were drastically reduced, and substituted by astrocytic expansions. (B) High magnification of the SVZ dorsal horn with expansions rich in intermediate filaments (asterisks) in ENU animals. (C) Ependymal cell and neuroblasts frequently presented direct contact (arrow heads) in SVZ of treated animals. (D) Synaptic contacts located next to ependymal cell in animals exposed to ENU. (E) Large portions of basal membranes were observed between ependymal cells (arrows). (F) Myelinated and unmyelynated axons (arrows) were located between type A cells that composed chains, in ENU animals. Lv: lateral ventricle. Scale bar: A,F 10 µm, B 500 nm, C–E 2 µm.