Detection of gp350 antibody by luciferase immunoprecipitation assay in rhesus monkeys immunized with soluble gp350, VRP-gp350, a combination of VRP-350, VRP-EBNA-3A, and VRP-EBNA-3B, or PBS before challenge with wild-type virus.

<p>gp350 antibody levels in naturally infected monkeys are shown. Antibody levels are measured as luminometer units. Cut off value is shown as horizontal dotted line, which was determined as the mean +2 standard deviations of the blank signal (open circles). Horizontal bars indicate geometric mean, asterisks indicate p<0.05 (Mann-Whitney's U-test), NS indicates not significant.