BDNF release and effect of exogenous BDNF, pro-BDNF, TrkB inhibitor (K252a) and neutralizing anti-BDNF on apoptosis and proliferation in metastatic CRC cell lines.

<p>Results are expressed as relative units of proliferating cells (EDU) or apoptotic ratios of soluble nucleosomes detected by ELISA Cell Death (ECD) after 24 to 72 hours (H) of serum deprivation (0% FCS). Mean ± SEM of at least three independent experiments.</p><p>*, <i>p</i><0.05;</p><p>**, <i>p</i><0.01;</p><p>***, <i>p</i><0.001, compared with serum-free condition alone (0% FCS).