Preservation of bipolar cells in A2−/− OIR retina.

<p>A) Immunostaining of WT RA, WT OIR and A2−/−OIR retinal sections at P17 using rod bipolar cell marker PKCα. Scale bar 100 µm B) High magnification images of rod bipolar cells demonstrating the neurodegeneration of rod bipolar cells in WT OIR retina. Scale bar 25 µm. C) Quantification of PKCα positive cells showing significantly increased number in A2−/−OIR retina compared to WT OIR. Data presented as mean±SD. §WT RA vs WT OIR (P<0.01), * A2−/− OIR vs WT OIR (P<0.05), N varies from 3–4. GCL, ganglion cell layer; IPL, inner plexiform layer; INL, inner nuclear layer; OPL, outer plexiform layer; ONL, outer nuclear layer.