<p><b>A.</b> Original current traces of a typical wt, mdx, and mdx-utr cardiomyocyte, elicited by the pulse protocol in B. <b>B.</b> Current-voltage relationships derived from a series of experiments as shown in A. <b>C.</b> Maximum current densities in wt and dystrophic cardiomyocytes. *** indicates that ANOVA revealed a significant difference (p<0.001) between the three tested groups. <b>D.</b> Comparison of the voltage-dependencies of activation and steady-state inactivation between wt and dystrophic cardiomyocytes. For detailed statistics and n-values see <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0020300#pone-0020300-t001" target="_blank">Table 1</a>.</p
BACKGROUND: The SCN5A encoded sodium current (I(Na)) generates the action potential (AP) upstroke an...
Background: The SCN5A encoded sodium current (INa) generates the action potential (AP) upstroke and ...
<p>A. Voltage-dependence of activation (One-way-ANOVA: F<sub>(3,65)</sub> = 6.67, p<0.0005, post-hoc...
<p><b>A.</b> Original current traces of a typical wt, mdx, and mdx-utr cardiomyocyte, elicited by de...
<p>The given parameters were obtained by the analysing procedures described in <a href="http://www.p...
<p><b>A.</b> Original barium current traces (five episodes displayed) of a wt and mdx-utr cardiomyoc...
<p>Typical AP of a wt cardiomyocyte (top left) elicited by a 4-ms current injection at 125% threshol...
<p>(A) Whole-cell sodium current traces in response to increasing step depolarizations in WT (left) ...
Voltage-gated calcium currents and potassium currents were shown to undergo developmental changes in...
Duchenne muscular dystrophy (DMD), caused by mutations in the dystrophin gene, is associated with se...
The sodium (Na) channel is the fundamental unit of excitability in heart muscle. This channel has be...
The different sodium channel currents (INa) were reported in myocardium, neuron, and skeletal muscle...
In this study we have expressed and characterized recombinant cardiac and skeletal muscle sodium cha...
Voltage-gated sodium channels are crucial to action potential propagation in excitable tissues. Beca...
<p>A. Current-voltage (I-V) relationship of transient I<sub>Na</sub>. Peak transient I<sub>Na</sub> ...
BACKGROUND: The SCN5A encoded sodium current (I(Na)) generates the action potential (AP) upstroke an...
Background: The SCN5A encoded sodium current (INa) generates the action potential (AP) upstroke and ...
<p>A. Voltage-dependence of activation (One-way-ANOVA: F<sub>(3,65)</sub> = 6.67, p<0.0005, post-hoc...
<p><b>A.</b> Original current traces of a typical wt, mdx, and mdx-utr cardiomyocyte, elicited by de...
<p>The given parameters were obtained by the analysing procedures described in <a href="http://www.p...
<p><b>A.</b> Original barium current traces (five episodes displayed) of a wt and mdx-utr cardiomyoc...
<p>Typical AP of a wt cardiomyocyte (top left) elicited by a 4-ms current injection at 125% threshol...
<p>(A) Whole-cell sodium current traces in response to increasing step depolarizations in WT (left) ...
Voltage-gated calcium currents and potassium currents were shown to undergo developmental changes in...
Duchenne muscular dystrophy (DMD), caused by mutations in the dystrophin gene, is associated with se...
The sodium (Na) channel is the fundamental unit of excitability in heart muscle. This channel has be...
The different sodium channel currents (INa) were reported in myocardium, neuron, and skeletal muscle...
In this study we have expressed and characterized recombinant cardiac and skeletal muscle sodium cha...
Voltage-gated sodium channels are crucial to action potential propagation in excitable tissues. Beca...
<p>A. Current-voltage (I-V) relationship of transient I<sub>Na</sub>. Peak transient I<sub>Na</sub> ...
BACKGROUND: The SCN5A encoded sodium current (I(Na)) generates the action potential (AP) upstroke an...
Background: The SCN5A encoded sodium current (INa) generates the action potential (AP) upstroke and ...
<p>A. Voltage-dependence of activation (One-way-ANOVA: F<sub>(3,65)</sub> = 6.67, p<0.0005, post-hoc...