<p>Table shows summary of clinical observations following intrathecal injection of BoNT-B in mouse. Maximal tolerable dose was determined to be BoNT-B 0.5 U/5 µL.</p><p>*Clinical observation was made at time of sacrifice.</p
<p>A) Time course of formalin-evoked flinching behavior measured up to 40 mins after formalin. Mice ...
<p>Symptoms of intoxication and time to death were monitored following administration of the indicat...
Faced with the novelty of a 212Pb-labeled monoclonal antibody (mAb) for clinical translation, concer...
<p>A 10 LD<sub>50</sub> dose of BoNT/A1 was administered by intraperitoneal injection to groups of f...
<p>BoNT/A (10 LD50) was administered via intra-peritoneal injection to Swiss ...
<p>Mice were treated with ip injection of vehicle (V), SB 203580 (SB), G-CSF (CSF), or both (C+S) af...
<p>Magnification 100. The mice were respectively injected RDP, pVAX-BDNF and RDP/pVAX-BDNF (three mi...
<p>Effective binding concentrations of BoNT-B and antibody were determined by titer assay on NativeP...
<p>A)Time course (left panel) of observed flinching behavior and histogram of phasic cumulative flin...
<p>Mice were treated with ip injection of vehicle (V), SB 203580 (SB), G-CSF (CSF), or both (C+S) af...
<p>Mice received i.v biotinylated mAbs 6A and 4LCA (0.75 µg of each) and...
<p><b>At sacrifice, femurs were collected for endpoint analysis of bone quality</b>. (A), bone mine...
<p>Schematic illustration of bortezomib treatment in C57B mice. Mice fed <i>ad libitum</i> received ...
<p>Mice were treated with ip injection of vehicle (V), SB 203580 (SB), G-CSF (CSF), or both (C+S) af...
<p>Two-month-old C57BL/6 mice received whole body irradiation (4 Gy) and immediately after (∼15 min)...
<p>A) Time course of formalin-evoked flinching behavior measured up to 40 mins after formalin. Mice ...
<p>Symptoms of intoxication and time to death were monitored following administration of the indicat...
Faced with the novelty of a 212Pb-labeled monoclonal antibody (mAb) for clinical translation, concer...
<p>A 10 LD<sub>50</sub> dose of BoNT/A1 was administered by intraperitoneal injection to groups of f...
<p>BoNT/A (10 LD50) was administered via intra-peritoneal injection to Swiss ...
<p>Mice were treated with ip injection of vehicle (V), SB 203580 (SB), G-CSF (CSF), or both (C+S) af...
<p>Magnification 100. The mice were respectively injected RDP, pVAX-BDNF and RDP/pVAX-BDNF (three mi...
<p>Effective binding concentrations of BoNT-B and antibody were determined by titer assay on NativeP...
<p>A)Time course (left panel) of observed flinching behavior and histogram of phasic cumulative flin...
<p>Mice were treated with ip injection of vehicle (V), SB 203580 (SB), G-CSF (CSF), or both (C+S) af...
<p>Mice received i.v biotinylated mAbs 6A and 4LCA (0.75 µg of each) and...
<p><b>At sacrifice, femurs were collected for endpoint analysis of bone quality</b>. (A), bone mine...
<p>Schematic illustration of bortezomib treatment in C57B mice. Mice fed <i>ad libitum</i> received ...
<p>Mice were treated with ip injection of vehicle (V), SB 203580 (SB), G-CSF (CSF), or both (C+S) af...
<p>Two-month-old C57BL/6 mice received whole body irradiation (4 Gy) and immediately after (∼15 min)...
<p>A) Time course of formalin-evoked flinching behavior measured up to 40 mins after formalin. Mice ...
<p>Symptoms of intoxication and time to death were monitored following administration of the indicat...
Faced with the novelty of a 212Pb-labeled monoclonal antibody (mAb) for clinical translation, concer...
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