Plot of the top multipoint linkage peak on chromosome 18.

<p>SNP markers are plotted along the x-axis by their deCODE map position, and the LOD/HLOD scores for each marker are plotted along the y-axis. The results of the FASTLINK/HOMOG dominant two-point analysis are indicated with black circles, and the results of the MERLIN dominant multipoint analysis are indicated with a black line. The SNP rs4941043 is the peak marker from the two-point analysis (see <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0018044#pone-0018044-t003" target="_blank"><b>Table 3</b></a>). The location of the <i>FCD2</i> peak (Sundin <i>et al.</i>, 2006) and the most significantly associated SNP, rs613872, from the FECD GWAS performed by Baratz <i>et al.</i> (2010) are indicated by arrows. The location of the <i>TCF4</i> gene is also indicated for reference. 2PT, two-point results; MPT, multipoint results; cM, centiMorgans; LOD, logarithm of the odds; HLOD, heterogeneity logarithm of the odds.