Effect of GSK101 on the plasma membrane expression of TRPV4 channel in HeLa-TRPV4 cells, over the time course of 30 min.
- Min Jin (333526)
- Zizhen Wu (356029)
- Ling Chen (25698)
- Jose Jaimes (356030)
- Diana Collins (356031)
- Edgar T. Walters (356033)
- Roger G. O'Neil (346763)
Publication date
February 2013
DOIAbstract
<p>A. Western blots showing that GSK101 caused a downregulation of TRPV4 in the pure plasma membrane fractions, while having no significant effect on the TRPV4 abundance in the post-nuclear (whole cell) lysates. B. Densitometry of the normalized TRPV4/cadherin ratio on the plasma membrane showed the statistically significant downregulation of TRPV4 under GSK101 treatment in HeLa-TRPV4 cells (Mean ± SE, n = 5, P<0.05).</p
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