Auditory function abnormalities in <i>Slitrk6</i>-KO mice.

<p>(A) Representative waves of auditory brainstem response (ABR) from WT (left, <i>n</i> = 7) and <i>Slitrk6</i>-KO (right, <i>n</i> = 9) mice. ABR were recorded upon 0- to 80-dB sound pressure level (SPL) stimuli of 2, 4, 8, 16, and 24 kHz. The dash lines indicate the time of click presentation. The scale bars are shown at bottom right. (B) ABR thresholds in WT and <i>Slitrk6</i>-KO mice. <i>Slitrk6</i>-KO mice showed significantly higher thresholds to the 8- and 16-kHz stimuli than those of WT mice. (C) <i>Top:</i> Each peak number in a representative ABR wave. <i>Middle:</i> Comparison of the values of peaks I, II, and III between WT and <i>Slitrk6</i>-KO mice. Peak I of <i>Slitrk6</i>-KO mice was significantly reduced in the range of 8 to 16 kHz, and peak III was also significantly reduced at 24 kHz. <i>Bottom:</i> The latency to peaks I, II, and III. The latency did not show clear differences between WT and <i>Slitrk6</i>-KO mice. (D) Auditory startle response of WT (<i>n</i> = 10) and <i>Slitrk6</i>-KO mice (<i>n</i> = 10). <i>Slitrk6</i>-KO mice showed significantly lower startle responses to 95- to 120-dB sounds. *<i>P</i><0.05, **<i>P</i><0.01. All bars are mean ± standard error of the mean.