<p>Compounds tested for their ability to overcome the anti-myogenic effect of TGF-β1 in C2C12 cells.</p
<p>A. Immunoblots of EGFR at different time points after treatment with <b>1</b> at different concen...
<p>(A) Zymogram of conditioned media derived from HTM cells treated with vehicle or TGF-β in the pre...
<p>Panel A: Anti-TGF-β1 (50 µg/ml) reversed the antiproliferative effect of ASA (2 mM). Panel B: ASA...
<p>Vehicle control had no effect on C2C12 differentiation or cell proliferation (A and E) (scale bar...
<p>C2C12 cells were treated with different concentrations of TGF-β1 for 96 hours and stained for nuc...
(A) Measurement of pharmacological inhibitors on TGFβ1 signaling. Cells were pretreated with the ind...
Transforming growth factor beta 1 (TGF-β1) is an inhibitor of muscle cell differentiation that is as...
Transforming growth factor beta 1 (TGF-β1) is an inhibitor of muscle cell differentiation that is as...
<p>Hit compounds of the primary screen were retested in replicates at 3 and 10 µM against HMGB1 and ...
<p>(A) Smad2/3 nuclear localization (Ai, green) and <i>CXCR4</i> expression (Aii) in TGF-β-treated 6...
<p>The effect of TGF-β1 (0.1 and 10 ng/ml) and PDGF (1 and 10 ng/ml) with or without the growth fact...
<p>TGF-β1 (50 pM) was used to inhibit C2C12 differentiation. (A) Increasing concentrations of SB4315...
<p><i>In vitro</i> inhibitory effects of compounds 1a-2b against the proliferation of three human ca...
<p>Subconfluent VSMCs were stimulated for 48(20 ng/mL, every 24 h) or TGFβ (1 ng/mL), alone or in co...
<p>Compounds tested as inhibitors of the NF-κB:DNA-recognition target complex formation.</p
<p>A. Immunoblots of EGFR at different time points after treatment with <b>1</b> at different concen...
<p>(A) Zymogram of conditioned media derived from HTM cells treated with vehicle or TGF-β in the pre...
<p>Panel A: Anti-TGF-β1 (50 µg/ml) reversed the antiproliferative effect of ASA (2 mM). Panel B: ASA...
<p>Vehicle control had no effect on C2C12 differentiation or cell proliferation (A and E) (scale bar...
<p>C2C12 cells were treated with different concentrations of TGF-β1 for 96 hours and stained for nuc...
(A) Measurement of pharmacological inhibitors on TGFβ1 signaling. Cells were pretreated with the ind...
Transforming growth factor beta 1 (TGF-β1) is an inhibitor of muscle cell differentiation that is as...
Transforming growth factor beta 1 (TGF-β1) is an inhibitor of muscle cell differentiation that is as...
<p>Hit compounds of the primary screen were retested in replicates at 3 and 10 µM against HMGB1 and ...
<p>(A) Smad2/3 nuclear localization (Ai, green) and <i>CXCR4</i> expression (Aii) in TGF-β-treated 6...
<p>The effect of TGF-β1 (0.1 and 10 ng/ml) and PDGF (1 and 10 ng/ml) with or without the growth fact...
<p>TGF-β1 (50 pM) was used to inhibit C2C12 differentiation. (A) Increasing concentrations of SB4315...
<p><i>In vitro</i> inhibitory effects of compounds 1a-2b against the proliferation of three human ca...
<p>Subconfluent VSMCs were stimulated for 48(20 ng/mL, every 24 h) or TGFβ (1 ng/mL), alone or in co...
<p>Compounds tested as inhibitors of the NF-κB:DNA-recognition target complex formation.</p
<p>A. Immunoblots of EGFR at different time points after treatment with <b>1</b> at different concen...
<p>(A) Zymogram of conditioned media derived from HTM cells treated with vehicle or TGF-β in the pre...
<p>Panel A: Anti-TGF-β1 (50 µg/ml) reversed the antiproliferative effect of ASA (2 mM). Panel B: ASA...
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