SL142 and SL325 suppressed cell growth and induced apoptosis in H441 and A549 lung cancer cells.

<p><b>A</b>. Analysis of caspase-3 activity in A549, H441 and H1299 lung cancer cells after SAHA, SL142 and SL325 treatment. Cells were treated with SAHA, SL142 or SL325 at a concentration of 2.5 µM for 36 hours. Triplicate experiments were performed; data represent the mean-fold increase ± S.E. Significant difference from cells treated with PBS and cells treated with HDAC inhibitors indicated was shown (*p<0.05, **<0.01). <b>B</b>. Flow cytometric analysis of apoptosis induced by SAHA, SL142 or SL325. Cells were infected with SAHA, SL142 or SL325 at the concentration of 2.5 µM for 72 hours and sub-G₀/G₁ DNA content was measured by propidium iodide staining and flow cytometric analysis.