Suberoylanilide hydroxamic acid (SAHA) is a well-known pan HDAC inhibitor, and its clinical application (Vorinostat) has been demonstrated to treat nonsmall cell lung cancer (NSCLS). Nevertheless, the impact of SAHA treatment on histone lysine acetylation and proteome in NSCLS cells still need further elucidate. In NSCLS A549 cells, by using stable isotope labeling for cell culture (SILAC)-based quantitative proteomics, biochemistry assay, and bioinformatic analysis, here we for the first time comprehensively identified and quantified histone lysine acetylation in A549 cells toward SAHA treatment. Despite the fact that SAHA treatment significantly increased histone lysine acetylation in specific sites, unexpectedly, some important “histone ...
Epigenetic dysregulations are linked to many human diseases including neurodegenerative disorders, i...
Histone deacetylase (HDAC) inhibitors represent a promising group of anticancer agents. This paper s...
[[abstract]]Purpose: Recent studies have shown that overexpression and/or increased activity of hist...
Suberoylanilide hydroxamic acid (SAHA) is a well-known pan HDAC inhibitor, and its clinical applicat...
Emerging evidence suggests that suberoylanilide hydroxamic acid (SAHA), a clinically approved HDAC i...
Objective. Our study analyzed the effects of HDAC inhibitor SAHA treatment on gene expressions of Ch...
SAHA (suberoylanilide hydroxamic acid or vorinostat) is the first nonselective histone deacetylase (...
HSP60 undergoes changes in quantity and distribution in some types of tumors suggesting a participat...
xMedulloblastoma is one of the most common malignant childhood brain tumors. Although advances in mu...
BACKGROUND: Lung cancer is the leading cause of cancer mortality worldwide, yet the therapeutic stra...
Uncontrolled cell proliferation and resistance to apoptosis in cancer are, among others, regulated b...
Histone proteins are subject to a range of post-translational modifications in living cells. The com...
Shu-Ting Pan,1,* Zhi-Wei Zhou,2,3,* Zhi-Xu He,3 Xueji Zhang,4 Tianxin Yang,5 Yin-Xue Yang,6 Dong Wan...
Objective: We analyzed the expression of PD-L1 following inhibition of HDACs (Histone Deacetylase) w...
Objective: Our study was aimed to examine the expression levels of DNA methyltransferase in HCC827 (...
Epigenetic dysregulations are linked to many human diseases including neurodegenerative disorders, i...
Histone deacetylase (HDAC) inhibitors represent a promising group of anticancer agents. This paper s...
[[abstract]]Purpose: Recent studies have shown that overexpression and/or increased activity of hist...
Suberoylanilide hydroxamic acid (SAHA) is a well-known pan HDAC inhibitor, and its clinical applicat...
Emerging evidence suggests that suberoylanilide hydroxamic acid (SAHA), a clinically approved HDAC i...
Objective. Our study analyzed the effects of HDAC inhibitor SAHA treatment on gene expressions of Ch...
SAHA (suberoylanilide hydroxamic acid or vorinostat) is the first nonselective histone deacetylase (...
HSP60 undergoes changes in quantity and distribution in some types of tumors suggesting a participat...
xMedulloblastoma is one of the most common malignant childhood brain tumors. Although advances in mu...
BACKGROUND: Lung cancer is the leading cause of cancer mortality worldwide, yet the therapeutic stra...
Uncontrolled cell proliferation and resistance to apoptosis in cancer are, among others, regulated b...
Histone proteins are subject to a range of post-translational modifications in living cells. The com...
Shu-Ting Pan,1,* Zhi-Wei Zhou,2,3,* Zhi-Xu He,3 Xueji Zhang,4 Tianxin Yang,5 Yin-Xue Yang,6 Dong Wan...
Objective: We analyzed the expression of PD-L1 following inhibition of HDACs (Histone Deacetylase) w...
Objective: Our study was aimed to examine the expression levels of DNA methyltransferase in HCC827 (...
Epigenetic dysregulations are linked to many human diseases including neurodegenerative disorders, i...
Histone deacetylase (HDAC) inhibitors represent a promising group of anticancer agents. This paper s...
[[abstract]]Purpose: Recent studies have shown that overexpression and/or increased activity of hist...