The SNX-PX-BAR family is involved in macropinosome formation.

<p>HEK-Flp-In cells transiently overexpressing GFP-tagged members of the SNX-PX-BAR family were assayed for macropinosome formation as described in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0013763#s4" target="_blank">Materials and Methods</a>. A: Dextran-TR labeling of cells transfected with the specified constructs. Scale bar = 10 µm. B: The mean number of macropinosomes/100 transfected cells was quantitated over 8 replicates of 500 transfected cells for each condition. * denotes statistical significance (p<0.05) using the Student's T-test, performing pairwise analyses relative to cells transfected with pEGFP-C1 alone. Error bars denote S.E.M.