Viral production rates in the lymphoid tissue estimated by Reilly <i>et al.</i>[<b>23</b>] for resting (panels a,c) and activated cells (b,d) respectively.

<p>The top row of the Figure (Panels a,b) is the result when the mean of the prior distribution of the half-life resting cells is 4 days (and that of activated cells is 1.5 days). In the bottom row (c,d) the mean of the prior distribution of the half-life resting cells is 14 days (and that of activated cells remains 1.5 days). The median total production rate per cell is computed by integrating these curves up to the half-life of the cell (as indicated by the heavy lines) and amounts to 1479 and 1395 virions per activated cell and 644 and 3405 per resting cell (see the text). The horizontal and vertical lines marked by crosses denote the mean value with 95% credible intervals for the production rate at time zero, the half-life of the cell, and the saturation time of the production function <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1000906#pcbi.1000906-Reilly1" target="_blank">[23]</a>.