Probability distribution of number of viral replications following activation of a latently infected cell.

<p>(a) Probability of the number of rounds of viral replication following the activation of a single latently infected cell, assuming drug efficacy <i>ε</i> = 0.999, 0.99, and 0.9, which are associated with reproductive ratios <i>R</i> = 0.0023, 0.023, and 0.23, and initial viral loads <i>V</i>₀ = 3, 3.1, and 4 copies/mL, respectively. (b) The probability of the maximum number of rounds of viral replication achieved as a function of the number of latent cell activations, using <i>ε</i> = 0.99, which is associated with <i>R</i> = 0.023 and initial viral load <i>V</i>₀ = 3.1 copies/mL. Note that these are discrete distribution functions, with the dots in (a) indicating probability of cells achieving <i>k</i> generations; the lines are included for clarity and have no meaning.