Altered distribution pattern of kisspeptin immunostaining in the ARC of <i>hpg</i> mice.

<p>Kisspeptin ICC across postnatal development (age 10, 30, 45 and 60 days) in WT and <i>hpg</i> females (<b>A</b>) and males (<b>B</b>). Kisspeptin ICC staining pattern in the ARC of both female and male WT mice (<i>left of dashed line</i>) is dominated by densely stained fibers that obscure kisspeptin-positive cell bodies (<i>white arrowheads</i>). In <i>hpg</i> mice (<i>right of dashed line</i>), ARC kisspeptin ICC shows reduced fiber staining and increased clusters of large, darkly stained cell bodies (<i>black arrowheads</i>). Scale bar = 200 µm.