<p>A. <i>Left</i>, Negative control for TFF2 staining in areas of GCP from a <i>Kcne2</i><sup>−/−</sup> mouse, using IgM isotype. Scale bar, 70 µm. <i>Right</i>, TFF2 staining in areas of GCP from a <i>Kcne2</i><sup>−/−</sup> mouse, using IgG isotype. Scale bar, 50 µm. B. TFF2 staining in cystic region of gastric mucosa from a <i>Kcne2</i><sup>−/−</sup> mouse. Scale bar, 50 µm. C. Increased magnification views of TFF2 staining in gastric mucosa from a <i>Kcne2</i><sup>−/−</sup> mouse. <i>Left</i>, gastric gland cross-section; <i>right</i>, gastric gland longitudinal section. Scale bar, 50 µm.</p
<p>(A) CTSE immunostaining (left panel) and HE staining (right panel) of the stomach showing the mix...
<p>(A–C) CDX2, a marker of intestinal metaplasia (IM), immunostaining in adult colon (positive contr...
<p>A) Schematic representation of LacZ substitution for the Gli1 gene to generate Gli1<sup>+/−</sup>...
<p>A. Mean stomach weights of <i>Kcne2</i><sup>+/+</sup> and <i>Kcne2</i><sup>−/−</sup> mice at 3 we...
Intestinal-type gastric adenocarcinoma evolves in a field of pre-existing metaplasia. Over the past ...
<p>A. Western blots of lysates from 3 stomachs per genotype from <i>Kcne2</i><sup>−/−</sup> and <i>K...
BACKGROUND & AIMS: The loss of parietal cells from the fundic mucosa leads to the emergence of metap...
Gastric cancer in humans arises in the setting of oxyntic atrophy (parietal cell loss) and attendant...
OBJECTIVES: Spasmolytic polypeptide-expressing metaplasia (SPEM) develops as a preneoplastic lesion ...
Objectives: Spasmolytic polypeptide-expressing metaplasia (SPEM) develops as a preneoplastic lesion ...
Gastric carcinogenesis involves the loss of parietal cells (oxyntic atrophy) and subsequent replacem...
<p>Mice were injected with an AAV vector expressing TFF3 or a control empty vector, or mice were tre...
Intestinal-type gastric adenocarcinoma evolves in a field of pre-existing metaplasia. Over the past ...
The development of intestinal-type gastric cancer is preceded by loss of parietal cells (oxyntic atr...
The dysplasia marker gene Trop2 is rarely detected in the central epithelial megacluster, whereas Mu...
<p>(A) CTSE immunostaining (left panel) and HE staining (right panel) of the stomach showing the mix...
<p>(A–C) CDX2, a marker of intestinal metaplasia (IM), immunostaining in adult colon (positive contr...
<p>A) Schematic representation of LacZ substitution for the Gli1 gene to generate Gli1<sup>+/−</sup>...
<p>A. Mean stomach weights of <i>Kcne2</i><sup>+/+</sup> and <i>Kcne2</i><sup>−/−</sup> mice at 3 we...
Intestinal-type gastric adenocarcinoma evolves in a field of pre-existing metaplasia. Over the past ...
<p>A. Western blots of lysates from 3 stomachs per genotype from <i>Kcne2</i><sup>−/−</sup> and <i>K...
BACKGROUND & AIMS: The loss of parietal cells from the fundic mucosa leads to the emergence of metap...
Gastric cancer in humans arises in the setting of oxyntic atrophy (parietal cell loss) and attendant...
OBJECTIVES: Spasmolytic polypeptide-expressing metaplasia (SPEM) develops as a preneoplastic lesion ...
Objectives: Spasmolytic polypeptide-expressing metaplasia (SPEM) develops as a preneoplastic lesion ...
Gastric carcinogenesis involves the loss of parietal cells (oxyntic atrophy) and subsequent replacem...
<p>Mice were injected with an AAV vector expressing TFF3 or a control empty vector, or mice were tre...
Intestinal-type gastric adenocarcinoma evolves in a field of pre-existing metaplasia. Over the past ...
The development of intestinal-type gastric cancer is preceded by loss of parietal cells (oxyntic atr...
The dysplasia marker gene Trop2 is rarely detected in the central epithelial megacluster, whereas Mu...
<p>(A) CTSE immunostaining (left panel) and HE staining (right panel) of the stomach showing the mix...
<p>(A–C) CDX2, a marker of intestinal metaplasia (IM), immunostaining in adult colon (positive contr...
<p>A) Schematic representation of LacZ substitution for the Gli1 gene to generate Gli1<sup>+/−</sup>...