Mean identity score <i>vs.</i> the folding free energy (top) and its components (middle, bottom), for seven proteins.

<p>Results are for the 8,000 lowest-energy designed sequences, which are compared to their corresponding native template. The size of each symbol indicates the number of sequences with the corresponding energy (energies binned in 10 kcal/mol windows). Negative energies indicate stable folding of the designed sequences.