Spirulina rats have a decreased astrocyte response to LPS.

<p>(<b>A</b>) LPS caused a significant increase in the percentage of the dentate gyrus which was GFAP positive. The spirulina fed rats had a reduced GFAP response LPS compare to the control diet fed rats with LPS. *** p = 0.0002 (NIH-31 vs. NIH-31+LPS). ††† P = 0.0003 (NIH-31+LPS vs. spirulina+LPS). (<b>B</b>) There was no significant difference in the total number of GFAP⁺ cells. (<b>C</b>) Representative photomicrograph of the GFAP immunohistochemical staining in the hippocampus. The white arrow points to the area shown in (<b>D</b>) at 20× magnification.