<p>Event-triggered T-type calcium currents were calculated for the model (first column) comparable to the experimental ETAs in <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1005960#pcbi.1005960.g006" target="_blank">Fig 6</a>; t = 0 indicates the peak of the (first) spike. Rows indicate the four different membrane states; blue traces indicate the current when a burst was induced, while green traces depict the situation for an isolated spike. The horizontal black line gives the mean value in the steady state condition. The inset zooms in around the time of initiation. The second column depicts the gating variables <i>m</i> (solid) and <i>h</i> (dashed) that underly the current using the same color code. The third...
<div><p>(A) Representative images in the control (left), CHT (middle), and DHT (right) groups. The c...
<p>(A) Mean voltage response (<i>n</i> = 4 cells) to a 30 Hz spike train. A hyperpolarizing current ...
Mammalian thalamocortical relay (TCR) neurons switch their firing activity between a tonic spiking a...
<p><b>A</b>) Summed input currents from both zones when the object moves from left to right (blue) a...
<p>Repeat of the experiment in <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal...
<p><b>A</b> Targeted juxtacellular recording of membrane potential from an unidentified HVC neuron (...
<p>The increase of the half-inactivation voltage of the slow calcium current, shifts towards more ...
(A–C) Voltage (A), cytosolic calcium (B) and phosphorylated CaMKII (C) traces recorded, at different...
<p>Voltage stimulus from −50 to 0 mV is shown in the top panel. The extracted time course of a calci...
<p>(A) A schematic indicating that the neuron model of a vestibular nuclei neuron with conductance b...
<p><b>A</b>: Representative traces of whole-cell <i>I</i><sub>Ca</sub> recordings with 2 mM [Ca<sup>...
Modeling the layer 5 pyramidal neuron as a system of three connected isopotential compartments, the ...
<p>The same computer generated frozen noise was injected into the TCR cell (solid line) and in the f...
A novel voltage-clamp protocol was developed to test whether slow inactivation of Ca2+ current occur...
<p>The amplitude of calcium spike represents the maximum fold change in cytosolic calcium level. The...
<div><p>(A) Representative images in the control (left), CHT (middle), and DHT (right) groups. The c...
<p>(A) Mean voltage response (<i>n</i> = 4 cells) to a 30 Hz spike train. A hyperpolarizing current ...
Mammalian thalamocortical relay (TCR) neurons switch their firing activity between a tonic spiking a...
<p><b>A</b>) Summed input currents from both zones when the object moves from left to right (blue) a...
<p>Repeat of the experiment in <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal...
<p><b>A</b> Targeted juxtacellular recording of membrane potential from an unidentified HVC neuron (...
<p>The increase of the half-inactivation voltage of the slow calcium current, shifts towards more ...
(A–C) Voltage (A), cytosolic calcium (B) and phosphorylated CaMKII (C) traces recorded, at different...
<p>Voltage stimulus from −50 to 0 mV is shown in the top panel. The extracted time course of a calci...
<p>(A) A schematic indicating that the neuron model of a vestibular nuclei neuron with conductance b...
<p><b>A</b>: Representative traces of whole-cell <i>I</i><sub>Ca</sub> recordings with 2 mM [Ca<sup>...
Modeling the layer 5 pyramidal neuron as a system of three connected isopotential compartments, the ...
<p>The same computer generated frozen noise was injected into the TCR cell (solid line) and in the f...
A novel voltage-clamp protocol was developed to test whether slow inactivation of Ca2+ current occur...
<p>The amplitude of calcium spike represents the maximum fold change in cytosolic calcium level. The...
<div><p>(A) Representative images in the control (left), CHT (middle), and DHT (right) groups. The c...
<p>(A) Mean voltage response (<i>n</i> = 4 cells) to a 30 Hz spike train. A hyperpolarizing current ...
Mammalian thalamocortical relay (TCR) neurons switch their firing activity between a tonic spiking a...