Structural differences observed in the protein domain pairs.

<p>(<b>A</b>) RMSD and GDT distributions of the 20 protein domain pairs. The X-axis represents each domain pair in the dataset and the Y-axis represents the RMSD (left) and 100-GDT (right). (<b>B</b>) RMSD distribution of the protein domain pairs (colored cyan) and the control dataset 1 (colored pink). The distributions are significantly different, two-sample KS test; p-value: 1.26e-06. (<b>C</b>) 100-GDT distribution of the protein domain pairs (colored cyan) and the control dataset 1 (colored pink). The distributions are significantly different, two-sample KS test; p-value: 8.14e-06. (<b>D</b>) Distribution of the deviations observed for functional residues, interface residues and all the residues in the dataset. (<b>E</b>) Representative examples are shown for the types of local structural deviation observed in the dataset. The domain-domain interface regions are represented in sticks and the regions showing significant structural deviation are encircled in black.