Additional file 3: of Epigenome-wide analysis in newborn blood spots from monozygotic twins discordant for cerebral palsy reveals consistent regional differences in DNA methylation

Heat map of the associations between the six largest principal components and specified covariates. The heat map provides a score of the strength of the association between DNA methylation (using M values) and each covariate, with positive and negative correlations ranging according to the magnitude (red positive, blue negative). The values in brackets for each association represent the p-value of the correlation. Of the six significant (p < 0.05) associations, all are weak (correlation < 0.6). Abbreviations: CP, cerebral palsy; PC, principal component; PIC, person in charge of performing DNA extraction; GA, gestational age; GMFCS, gross motor function classification system; Guthrie age, age in postnatal days when Guthrie card was made. (PDF 53 kb