MiR-19a and miR-19b inhibitors induce cell apoptosis.

<p>(A) Flow cytometry results of Annexin-V5 analysis in 786-O cells transfected with miR-19a and miR-19b inhibitors. An inhibitor control was included as a negative control. Graphs showing changes of the apoptotic percentage of the cells (left); quantification of relative apoptosis (right). The data represent the means ± S.D. from three independent experiments performed in triplicate. *Significant differences from control oligo-transfected cells (P<0.05) (B) Western blot results showing the effect of miR-19a and miR-19b inhibitors on the expression of cleaved caspase-9 in 786-O cells. (C) Potential mechanism showing the effect of the negative regulation of RhoB by miR-19a/b on the proliferation, migration, invasion and apoptosis of ccRCC.