Voltage-gated currents were unaffected by high glucose conditions.

<p>A, show representative traces of macroscopic voltage-gated outward and inward currents recorded in voltage-clamp mode (holding potential set at -60 mV) by the application of a voltage step protocol (inset), in cultured DRG neurons maintained in either control (CTL, top traces) or high glucose (HG, bottom traces). B-C, the I-V plot summarize the mean outward current density (B) and mean inward peak current density (C) obtained at different step voltages, in both experimental conditions. All data are represented as mean ± SEM, n = 5 for each condition.