<p>We compare <i>pathfinder</i> to the technique of independently fine-mapping the two levels of data, with respect to (A) the calibration of their credible sets and (B) the size of their credible sets. In (A), we compare the proportion of causal variants that were captured in the 90% credible sets using <i>pathfinder</i> vs. independent fine-mapping against the expected proportion (represented by the dotted line). In (B), we display the corresponding sizes of these credible sets.</p
When statistical linkage to a certain chromosomal region has been found, it is of interest to develo...
Interpretation of dense single nucleotide polymorphism (SNP) follow-up of genome-wide association or...
<p>Methods were benchmarked using the average number of SNPs per locus selected to find (50%,90%) of...
<p>We compare <i>pathfinder</i> to basic eQTL mapping, with respect to the size of their credible se...
<p>We compare <i>pathfinder’s</i> performance when using SNP LD from YRI vs from CEU, with respect t...
<p>The y-axis shows the number of variants in the 95% (a) and 99% (b) likely credible sets. The boxp...
<p>(A) Distances from SNP to mark (B) Distances from mark to TSS (C) Distances from SNP to TSS.</p
We simulated 13082 phenotypes using 100 loci of ∼200 SNPs, as described in the main text. Panels (a)...
<p>We simulated quantitative phenotype data with between two and five causal variants using genotype...
Genome Wide Association Studies (GWAS) have successfully identified thousands of loci associated wit...
<p>(A-C) <i>pathfinder</i>’s SNP-, mark-, and path-mapping accuracy for standard simulations compare...
<p>Fraction of the simulations where the fine-mapped set is reduced to fewer than 10 variants for th...
Genome Wide Association Studies (GWAS) have successfully identified thousands of loci associated wit...
Here, quantitative traits are simulated to have broad-sense heritability of H2 = 0.6 with contributi...
Here, quantitative traits are simulated to have broad-sense heritability of H2 = 0.2 with only contr...
When statistical linkage to a certain chromosomal region has been found, it is of interest to develo...
Interpretation of dense single nucleotide polymorphism (SNP) follow-up of genome-wide association or...
<p>Methods were benchmarked using the average number of SNPs per locus selected to find (50%,90%) of...
<p>We compare <i>pathfinder</i> to basic eQTL mapping, with respect to the size of their credible se...
<p>We compare <i>pathfinder’s</i> performance when using SNP LD from YRI vs from CEU, with respect t...
<p>The y-axis shows the number of variants in the 95% (a) and 99% (b) likely credible sets. The boxp...
<p>(A) Distances from SNP to mark (B) Distances from mark to TSS (C) Distances from SNP to TSS.</p
We simulated 13082 phenotypes using 100 loci of ∼200 SNPs, as described in the main text. Panels (a)...
<p>We simulated quantitative phenotype data with between two and five causal variants using genotype...
Genome Wide Association Studies (GWAS) have successfully identified thousands of loci associated wit...
<p>(A-C) <i>pathfinder</i>’s SNP-, mark-, and path-mapping accuracy for standard simulations compare...
<p>Fraction of the simulations where the fine-mapped set is reduced to fewer than 10 variants for th...
Genome Wide Association Studies (GWAS) have successfully identified thousands of loci associated wit...
Here, quantitative traits are simulated to have broad-sense heritability of H2 = 0.6 with contributi...
Here, quantitative traits are simulated to have broad-sense heritability of H2 = 0.2 with only contr...
When statistical linkage to a certain chromosomal region has been found, it is of interest to develo...
Interpretation of dense single nucleotide polymorphism (SNP) follow-up of genome-wide association or...
<p>Methods were benchmarked using the average number of SNPs per locus selected to find (50%,90%) of...