Population-specific design of de-immunized protein biotherapeutics - Fig 3

<p>Pareto front of de-immunized designs in percent change compared to the wild type with k = 1,2,3 mutations. Each design is a tradeoff between the immunogenicity and the protein fitness function and represents a new sequence (here represented as tertiary structures). Immunogenicity is approximated by the HLA binding affinity predictions for a set of HLA molecules weighted by their HLA allele frequency in a specific population. The red spheres within the tertiary structures mark the mutated residues.