Population-specific design of de-immunized protein biotherapeutics - Fig 5

<p>(A) Correlation of experimental and predicted immunogenicity of each peptide. The experimental immunogenicity score of a peptide is defined as the linear combination of the individual experimentally determined relative HLA binding affinity of each HLA allele h ∈ H weighted by the HLA allele frequency. (B) Correlation of experimental and predicted immunogenicity of the whole redesigned region. The summarized immunogenicity score of the whole region is the linear combination of the overlapping peptides used to reconstruct the region, normalized by total number of peptides used. The predicted immunogenicity scores per peptide were computed according to our immunogenicity objective function. The red lines are a fitted linear regression and the red tubes represent their 95-confidence interval.