Highly selective and immortal magnesium calixarene complexes for the ring-opening polymerization of rac-lactide

The lithiation of 1,3-dipropoxy-p-tert-butylcalix[4]arene (LH₂) followed by reaction with nBuMgBr in THF resulted in the formation of the hetero-bimetallic complex [Li(THF)Mg(nBu)L] (1). By contrast, the treatment of tripropoxy-p-tert-butylcalix[4]arene (L′H) with nBu₂Mg afforded a mononuclear complex [L′Mg(nBu)] (2). Single-crystal XRD studies revealed that in both structures the calix[4]arene adopts a cone conformation, and a Li cation resides in the cavity for 1. Both 1 and 2 were active for the ring-opening polymerisation of rac-lactide. Compound 2 displayed not only exceptional activity (100 equivalents, 3 min, 92 % conversion, BnOH, room temperature) but also high selectivity (probability to form an r dyad, Pᵣ=0.85) and exhibited an immortal character in THF. Surprisingly, compound 2 also showed isotactic bias (Pr=0.30–0.36) and an immortal character if toluene was employed as the solvent; 2 D J-resolved ¹H NMR spectroscopy was employed for the assignment of the stereoselectivity