Variation and significance of oxidative indexes, inflammatory factors and function of vascular endothelium in hypercholesterolemia patients

Objective: To investigate the variation and significance of oxidative stress indexes, inflammatory factors and function of vascular endothelium in hypercholesterolemia patients and offer relevant supports on clinical therapy for hypercholesterolemia patients. Methods: A total of 120 patients with hypercholesterolemia detected in our hospital were selected, and divided to two groups based on the course of disease: hypercholesterolemia group I (48 cases) and hypercholesterolemia group II (72 cases). A total of 80 healthy cases were selected as the control group. ELISA and color doppler ultrasonic diagnostic apparatus were utilized to detect the variations of oxidative stress indexes (MDA, SOD and GSH-Px), indexes of vascular endothelial function (SE, FMD and NMD), and inflammatory factors (IL-6, IL- 10, TNF-α and hs-CRP) in the three groups of people. Result: Detection of oxidative stress indexes found that MDA levels were lowest in control group, MDA levels were highest in hypercholesterolemia group II; SOD and GSH-Px levels were highest in control group, and compared with hypercholesterolemia group I, SOD and GSH-Px levels were significantly lower in group I. IL-6, TNF-α and hs-CRP levels were significantly higher in hypercholesterolemia group II than group I, and were lowest in control group; IL-10 levels were lowest in hypercholesterolemia group II, and were followed by group I. SE and NMD levels in hypercholesterolemia group II were significantly higher than in group I, and levels in group I were higher than in control group; FMD levels were lowest in hypercholesterolemia group II, and were followed by group I. Conclusions: Significant changes appeared on oxidative stress indexes, inflammatory factors and function of vascular endothelium in hypercholesterolemia patients. It is of vital significance for understanding the mechanism of hypercholesterolemia and relevant therapies