Gestational diabetes mellitus impairs fetal endothelial cell functions through a mechanism involving microRNA-101 and histone methyltransferase enhancer of zester homolog-2
- Floris, Ilaria
- Descamps, Betty
- Vardeu, Antonella
- Mitić, Tijana
- Posadino, Anna Maria
- Shantikumar, Saran
- Sala-Newby, Graciela
- Capobianco, Gianpiero
- Mangialardi, Giuseppe
- Howard, Lynsey
- Dessole, Salvatore
- Urrutia, Raul
- Pintus, Gianfranco
- Emanueli, Costanza
Publication date
January 2015
DOI Publisher
Ovid Technologies (Wolters Kluwer Health)Abstract
GDM impairs HUVEC function via miR-101 upregulation. EZH2 is both a transcriptional inhibitor and a target gene of miR-101 in HUVECs, and it contributes to some of the miR-101-induced defects of GDM-HUVECs
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