Intracellular calcium dynamics affect the circadian oscillatory behavior.

<p>Circadian profiles of the firing rate (A), intracellular calcium concentration (C) and <i>Per</i> mRNA concentration (D) are shown for the control (black line), ryanodine blockade (red dashed line) and nimodipine application (blue dotted line). B). % decrease in the firing rate, <i>Per</i> mRNA concentration, Ca²⁺ current (<i>I_Ca</i>) and cytosolic calcium concentration during the circadian night (green bars) and day (red bars) as a result of ryanodine blockade. E) % decrease in the firing rate, <i>Per</i> mRNA concentration, Ca²⁺ current (<i>I_Ca</i>) and Ca²⁺ -activated K⁺ current (<i>I_KCa</i>) during the circadian night (green bars) and day (red bars) as a result of nimodipine application. ** denotes very small changes of the perturbed value compared to the control.