vTK/GCV induced liver failure in FVB/N mice.
- Donna N. Douglas (366965)
- Toshiyasu Kawahara (366966)
- Banu Sis (366967)
- David Bond (89182)
- Karl P. Fischer (366968)
- D. Lorne J. Tyrrell (366969)
- Jamie T. Lewis (366970)
- Norman M. Kneteman (173215)
Publication date
February 2013
DOIAbstract
<p>GCV was administered to vTK+ and vTK-FVB/N mice for 5 days. Health status ranged from excellent (+++), to poor (++), to critical. ALT and AST levels were determined for blood draws obtained at 1 hour prior to (T<sub>0</sub>) and at the end of (T<sub>f</sub>) the dosing period. Livers ranged from healthy/normal (red), to very pale at the end of the study.</p
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