Systemic PrEP with FTC/TDF results in effective protection from intravenous HIV-1 transmission.

<p>(A) Kaplan-Meier plot of the time course to peripheral blood conversion following intravenous exposure to HIV-1 in BLT mice with or without systemic PrEP. (B) Seven (out of eight) mice receiving systemic PrEP were consistently negative for plasma viral RNA. Plasma viral RNA was detected in the systemic PrEP breakthrough mouse (#42) and the 6 non-treated control mice. Thin dashed line represents the limit of detection for this assay. (C) BLT mice receiving systemic PrEP were negative for PBMC-associated viral DNA by real time PCR. PBMC-associated viral DNA was detected in the systemic PrEP breakthrough mouse (#42) and the 6 non-treated control mice. (D) Average levels of human CD4⁺ T cells in peripheral blood showed loss of CD4⁺ T cells in the systemic PrEP breakthrough mouse (#42) and the 6 non-treated control mice. CD4⁺ T cells remained constant in the protected systemic PrEP treated BLT mice.