DAS181 inhibits pandemic IFV A(H1N1)-induced lethality in mice.
- Gallen B. Triana-Baltzer (258230)
- Larisa V. Gubareva (174066)
- John M. Nicholls (150882)
- Melissa B. Pearce (240529)
- Vasiliy P. Mishin (236284)
- Jessica A. Belser (204148)
- Li-Mei Chen (47129)
- Renee W. Y. Chan (263941)
- Michael C. W. Chan (263937)
- Maria Hedlund (258246)
- Jeffrey L. Larson (258251)
- Ronald B. Moss (258240)
- Jacqueline M. Katz (51849)
- Terrence M. Tumpey (43117)
- Fang Fang (38179)
Publication date
February 2013
DOIAbstract
<p>BALB/c mice were inoculated with the pandemic influenza A(H1N1) virus A/Mexico/4108/2009 (1000 MID<sub>50</sub>/mouse, <i>i.n.</i>). The mice were treated with PBS or DAS181 (0.3, 0.6, or 1 mg/kg) <i>q.d.x5</i>, beginning 6 hours post-infection. Survival was tracked daily for 14 days. Values represent percent survival amongst 10 mice per group. All DAS181 treated groups had 100% survival. Statistical significance from PBS determined by Kaplan-Meier Log Rank Test, * = p<.05.</p
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