Therapeutic potential of one versus two doses of the combination of chimeric mAbs in mice.

<p>Groups of mice (n = 10) were infected with mouse-adapted HPAI H5N1 from Clade 1 A/Vietnam/1203/2004 (A and C) and clade 2.1 virus A/TLL013/06 (B and D). For treatment with a single dose, 24 h after viral challenge, the mice were treated via intra-peritoneal route with 1.0 mg/kg, 2.5 mg/kg, 5 mg/kg or 0 mg/kg (PBS) of the combination of mAbs. For treatment with two doses, different sets of mice were treated twice with similar doses of chimeric mAbs 24 h and 72 h after the viral challenge. An irrelevant IgG1 monoclonal antibody (specific for porcine circovirus) was used as a negative control. Mice were monitored for survival (A and B) and weight loss (C and D) throughout a 14 day observation period. The results are expressed in terms of percent survival and percent body weight (at the beginning of the trial) respectively.