Evaluation of vaccination routes by low dose treatment with MVA-HA.

<p>Mice in groups of 5 were vaccinated with MVA or MVA-HA at the doses indicated in the legend. Booster vaccinations were administered after 3 weeks, and mice were challenged with 10⁶ pfu of influenza rgA/Viet Nam/1203/2004 (H5N1), three weeks after the second vaccination. Mice were weighed for 14 days post challenge. Weight loss as a measure of disease severity is shown in <b>A</b>, and the proportion of surviving animals in the different treatment groups are represented in <b>B</b>.