Correlation between four evolutionary factors.

<p>Shown are scatterplots for the differences in three physico-chemical properties and in the average codon sequence that are associated with the 190 possible amino acid exchanges (upper triangle of the scheme) and the corresponding correlation coefficients and p-values obtained in a Mantel test (lower triangle of the scheme). Differences in the physico-chemical properties are weakly correlated with average differences in the codon sequences. Abbreviations: HydroPhob, hydrophobicity; CodonDist, average codon distance.