MMTV-ΔN89β-catenin and MMTV-Wnt1 tumors show expansion of distinct CD24/CD49f cell populations.

<p>CD24/CD49f marker profile of (A) total, (B) EGFP- and (C) EGFP^hi cells from MMTV-ΔN89β-catenin tumors. Note the enrichment and upward shift of EGFP^hi cells within the CD24^high/CD49f^low subpopulation. CD24/CD49f marker profile of (D) total, (E) EGFP- and (F) EGFP^hi cells from MMTV-Wnt1 tumors. Note EGFP^hi cells are shifted rightward within the CD24^high/CD49f^low subpopulation and upward within the CD24^low/CD49f^high subpopulation. CD24/CD49f marker profile of (G) total cells from a <i>wt</i> littermate. (H) EGFP⁺ cells from MMTV-ΔN89β-catenin tumors show higher colony forming efficiency than EGFP⁽⁻⁾ and total sorted cells. (I) Immunofluorescence analysis shows these EGFP⁺ cells are generate colonies containing K14⁺ and K8⁺ cells.