Impaired regeneration in SRF deficient muscles.

<p>(A) Representative H&E-stained of transversal sections of TA muscles from control and mutant mice 21 days after CTX injection. Bars: 50 µm. (B) Frequency histogram showing distributions of myofibers CSA in control (white) and mutant (black) regenerated TA muscles 21 days after CTX injection (n = 5; 1000 myofibers were analysed for each muscle). (C) Sirius Red staining of transversal section of control and mutant TA muscle 21 days after CTX injection. Bars: 50 µm. (D, E) Maximal tetanic force, PO (D) and TA weight (E) were measured before and 21 days after CTX injection from control (white) and mutants (black) mice. (n = 5) *P<0.05 over control 21 days after CTX.