Solution and Gel Formulated Tenofovir Inhibited SIV_mac251/32H Infectivity In Vitro at Similar Doses and in the Same Range as for Representative HIV-1 Isolates

<p>Infection of TZM-bl indicator cells in the presence and absence of tenofovir was compared by luminescence analysis of cell lysates and the results expressed as percent inhibition. The graph shows the full titration of drug formulations on infection with SIV_mac251/32H; the virus stock used in subsequent challenge experiments in vivo. Each point represents the mean of three independent experiments performed in triplicate +/− standard deviation. The results for a panel of HIV-1 strains in comparison to SIV_mac251/32H are shown as IC₅₀ values in the inset.