GBV-C NS5A peptides downregulate CXCR4 expression.

<p>Cells expressing the full-length NS5A (1–414), the 152–167 and S158E peptide had significantly less CXCR4 on their surface than did cells containing the vector control (VC), frameshift (FS), scrambled 152–167 peptide sequence (Scr), or the S158G, and S158A peptides. Data represent the mean fluorescent intensity of CXCR4 on the surface of these cells measured by flow cytometry.