Partial Rescue of TTD Cutaneous, Blood, and Developmental Phenotypes in Compound Heterozygous <i>Xpd^TTD/†XPCS</i> Mice

<div><p>(A) Photographs of 5-mo-old homozygous <i>Xpd^TTD/TTD,</i> compound heterozygous <i>Xpd^TTD/†XPCS,</i> and wt mice. Insets: images of first-round hair loss.</p> <p>(B) Histological analysis of the skin of <i>Xpd^TTD/TTD, Xpd^TTD/†XPCS,</i> and wt mice. TTD-associated acanthosis (thicker epidermis, indicated by solid vertical line), pronounced granular layer (indicated by arrows), and sebacious gland hyperplasia (indicated by dotted vertical line) were absent in the epidermis of <i>Xpd^TTD/†XPCS</i> and wt mice. Magnification 400×.</p> <p>(C) Cysteine content of hair from wt, <i>Xpd^TTD/TTD,</i> and <i>Xpd^TTD/†XPCS</i> mice. The <i>p</i>-value indicates significant differences between mutants and wt, as well as between <i>Xpd^TTD/TTD</i> and <i>Xpd^TTD/†XPCS</i> mice. Error bars indicate standard error of the mean (SEM).</p> <p>(D) Hematocrit values from blood of <i>Xpd^TTD/TTD</i> and <i>Xpd^TTD/†XPCS</i> mice. The <i>p</i>-values indicate the significance of the difference relative to wt. Error bars indicate SEM.</p> <p>(E) Body weights of developing <i>Xpd^TTD/TTD</i> and <i>Xpd^TTD/†XPCS</i> mice after weaning plotted as a percentage of the weight of age-matched control wt and heterozygote (hz) littermates (set at 100%). Error bars indicate SEM.</p>