<div><p>(A–B) <i>myo-3</i> promoter driving-GFP reporters <i>(myo-3::Ngfp-lacZ</i>, <i>myo-3::Mtgfp)</i> displayed significant transgene silencing in the somatic tissues (mainly the muscles) in the <i>tam-1(cc567)</i> mutant (B), but not in the WT animals (A) [<a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.0020074#pgen-0020074-b011" target="_blank">11</a>].</p><p>(C–F) RNAi of the SynMuv suppressors, <i>mes-4</i> (C), <i>mrg-1</i> (D), and <i>isw-1</i> (E) as well as a non-SynMuv suppressor gene, <i>dcr-1</i> (F), restored GFP expression in the <i>tam-1(cc567)</i> mutant. <i>dcr-1</i> encodes the C. elegans Dicer protein that is required for <i>RNAi</i> [<a href="http://www.plosgenetics.org/article/info:doi/10.13...
AbstractTransposon jumps are a major cause of genome instability. In the C. elegans strain Bristol N...
<p>(A-D) <i>C</i>. <i>elegans mec-3</i> regulatory sequence drives expression of <i>mCherry</i> in a...
<p>The <i>gfp</i>-transgenic strain RT476 was transformed to express PPR3 or PPR3-Ala under a heat s...
<div><p>(A–D) DIC (A) and (C) and GFP fluorescence (B) and (D) images of hermaphrodite germline from...
<p><b>(A)</b> Schematic representation of the <i>in vivo</i> RNAi inhibition assay—the transgenes ex...
Context-dependent gene silencing is used by many organisms to stably modulate gene activity for larg...
<div><p>Gene inactivation through RNA interference (RNAi) has proven to be a valuable tool for study...
<p>The indicated <i>C. elegans</i> strains were raised on bacteria expressing <i>gfp</i> dsRNA, and ...
<p>Animals carrying promoter::gfp fusions to genes in key cytoprotective responses were exposed to s...
<p>(<b>A</b>) GFP fluorescence and stunted growth of the heat shock—treated <i>C</i>. <i>elegans</i>...
<p><b>(A)</b> The SIM in the CMM3 domain of MOM1 is not required for transcriptional silencing. As d...
<div><p>(A) The early larval arrest phenotype associated with the SynMuv B mutation <i>mep-1(lf)</i>...
<p>Expression of stress-responsive promoter::gfp fusions was quantified following treatment with an ...
<p>(<b>A</b>) Workflow of the suppressor screen identifying mutant <i>C</i>. <i>elegans</i> (red) wi...
<p>(A) Cartoon depicting the mutations made to the <i>M</i>. <i>hapla unc-47 cis</i> sequence, with ...
AbstractTransposon jumps are a major cause of genome instability. In the C. elegans strain Bristol N...
<p>(A-D) <i>C</i>. <i>elegans mec-3</i> regulatory sequence drives expression of <i>mCherry</i> in a...
<p>The <i>gfp</i>-transgenic strain RT476 was transformed to express PPR3 or PPR3-Ala under a heat s...
<div><p>(A–D) DIC (A) and (C) and GFP fluorescence (B) and (D) images of hermaphrodite germline from...
<p><b>(A)</b> Schematic representation of the <i>in vivo</i> RNAi inhibition assay—the transgenes ex...
Context-dependent gene silencing is used by many organisms to stably modulate gene activity for larg...
<div><p>Gene inactivation through RNA interference (RNAi) has proven to be a valuable tool for study...
<p>The indicated <i>C. elegans</i> strains were raised on bacteria expressing <i>gfp</i> dsRNA, and ...
<p>Animals carrying promoter::gfp fusions to genes in key cytoprotective responses were exposed to s...
<p>(<b>A</b>) GFP fluorescence and stunted growth of the heat shock—treated <i>C</i>. <i>elegans</i>...
<p><b>(A)</b> The SIM in the CMM3 domain of MOM1 is not required for transcriptional silencing. As d...
<div><p>(A) The early larval arrest phenotype associated with the SynMuv B mutation <i>mep-1(lf)</i>...
<p>Expression of stress-responsive promoter::gfp fusions was quantified following treatment with an ...
<p>(<b>A</b>) Workflow of the suppressor screen identifying mutant <i>C</i>. <i>elegans</i> (red) wi...
<p>(A) Cartoon depicting the mutations made to the <i>M</i>. <i>hapla unc-47 cis</i> sequence, with ...
AbstractTransposon jumps are a major cause of genome instability. In the C. elegans strain Bristol N...
<p>(A-D) <i>C</i>. <i>elegans mec-3</i> regulatory sequence drives expression of <i>mCherry</i> in a...
<p>The <i>gfp</i>-transgenic strain RT476 was transformed to express PPR3 or PPR3-Ala under a heat s...