SPM Maps of Brain Regions Showing Changes in Regional CMR_glc During Performance of DMS Task for Sleep Deprivation and Sleep Deprivation + CX717 Conditions

<div><p>(A–C) Maps are shown for the comparison of CMR_glc during DMS performance in sleep deprivation to normal vehicle conditions (see <a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.0030299#pbio-0030299-g007" target="_blank">Figure 7</a>C–<a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.0030299#pbio-0030299-g007" target="_blank">7</a>E). Decreases (blue) are shown for DPFC (A), DStr (B), and thalamus (Thal; C). Increases in CMR_glc (orange and yellow) are shown in C for MTL.</p> <p>(D–F) Maps shown for comparison of CMR_glc during DMS performance in sleep deprivation + CX717 (0.8 mg/kg, IV) to the sleep deprivation condition. Increases in CMR_glc were observed in DPFC (D) and DStr (E), whereas decreases were observed in MTL (F). Absence of labeled voxels for thalamus (Thal) in (F) indicates no change from sleep deprivation (C above) versus sleep deprivation + CX717 conditions.</p> <p>Regional changes are displayed on coronal sections of MR images of rhesus monkey brain at the level of the DPFC (A,D), DStr (B,E) and MTL (C,F). Statistical parametric maps were generated using SPM99 software. Colors indicate the location of clusters with a height threshold of <i>p</i> < 0.05 and spatial extent greater than 50 voxels. Color bars indicate <i>t</i> values (2–5; corresponding to <i>p</i> < 0.05 to <i>p</i> < 0.001, respectively) for significance of increase (red-yellow) or decrease (blue-green) in comparisons. Left and right hemispheres are on the left and right of images respectively.</p> <p>DOI: 10.1371/journal.pbio.0030299g008</p>