DTI detection of microstructural changes induced by sleep deprivation

Theme: Adapting MR in a Changing WorldTraditional Poster Session - Neuro A: Animal Models of Brain Disease Other Than Stroke: no. 0910Rapid eye movement (REM) sleep is believed to be critical for memory consolidation. To probe the microstructural changes after sleep deprivation (SD) in vivo, REM-SD and DTI were employed in this study. Significant axial, radial and mean diffusivity decreases were found bilaterally in various locations in hippocampus, suggesting specific layers of hippocampus such as dentate gyrus and CA1 may be more susceptible to SD. Significant FA, axial and mean diffusivity decreases were also detected in cortex. Our results indicated that DTI is sensitive for probing microstructural changes, and can provide insights into the microstructural plasticity associated with sleep and memory.link_to_OA_fulltextThe 20th Annual Meeting & Exihibition of the International Society of Magnetic Resonance in Medicine (ISMRM 2012), Melbourne, Australia, 5-11 May 2012. In Proceedings of 20th ISMRM, 2012, no. 091