Sequence Conservation in M10 and H-2 Loci

<div><p>(A) Ribbon diagram of the M10.5 α1–α2 platform with positions of residues that are 100% identical in the nine M10 and M1 families colored blue; residues that are among the top 10% most variable are colored red. Variability is determined by the number of amino acids at a given position divided by the frequency of the most common allele at that position. Residues 145–150, which are disordered, are designated by a dashed line.</p> <p>(B) Ribbon diagram of the H-2D^d α1–α2 domain. Conserved (blue) and highly variable (red) residues are derived from an alignment of 19 H-2D alleles [<a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.0030257#pbio-0030257-b80" target="_blank">80</a>].</p>